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Nevertheless, they are among the toughest biological materials, serving as a wide variety of interesting functions, e.g.scales to armor body, horns to combat aggressors, hagfish slime as defense against predators, nails and claws to increase prehension, hair and fur to protect against the environment.Rosalind Elsie Franklin was born in London, England.Her family was well-to-do and both sides were very involved in social and public works.A ubiquitous biological material, keratin represents a group of insoluble, usually high-sulfur content and filament-forming proteins, constituting the bulk of epidermal appendages such as hair, nails, claws, turtle scutes, horns, whale baleen, beaks, and feathers.These keratinous materials are formed by cells filled with keratin and are considered ‘dead tissues’.

Three-dimensional analysis found it is composed of a transmembrane component and cytoplasmic domain, while Mot A molecules were shown to form stable tetramer complexes with other Mot A molecules.Many motile bacteria have rotating fiber (flagellum) generating from a cell surface which functions like a screw and create a driving force to move or swim.At the proximal end of flagellum there is a rotary motor which is composed of a rotor and a stator and ions, Na or H , flow into cells by way of the stator.The pathogenic mutation examined weakens the ability of the chaperonin subunit to form stable hexadecamers and as a consequence, the chaperoning functions of the complex are impaired. The future prospect is to find means for stabilizing the hexadecamer, which should lead to a recovering of chaperone function and the improving of lesions and clinical condition.

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